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The role of MRI pelvis for predicting closure of perianal fistulas after treatment with anti-TNF alpha therapy in patients with Crohn’s disease


PI: Dr. Jeffrey McCurdy, University of Ottawa



Dr. Blair McDonald, University of Ottawa
Dr. Tim Ramsay, University of Ottawa
Dr. David Bruining, Mayo Clinic, Rochester, MN
Dr. Greg Rosenfeld, University of British Colombia
Dr. Talat Bessissow, McGill University
Dr. Vipul Jairath, University of Western Ontario



The aim of this study is to determine if clinical and radiologic variables are associated with fistula closure after initiating treatment with anti-TNF therapy. In so doing we aim to derive and validate an MRI-based predictive model to predict fistula.


Study Design

Multi-centre retrospective observational study. Patients will be identified by a search of institutional clinical databases and/or radiology databases from January 1, 2002 and July 1, 2020.


Participating Sites

Ottawa Hospital Research Institute (OHRI), ON
Mayo Clinic, Rochester, NY, USA
University of British Colombia, B.C.
McGill University Hospital, QC
University of Western Ontario, ON


For more information on Inclusion & Exclusion Criteria, click here.



Anticipated sample size: 300 patients
Anticipated start date: Recruiting
Anticipated end: 2022


Additional sites are welcome! Please contact Dr. Jeffrey McCurdy at jmccurdy@toh.ca or Jane Castelli jcast@mcmaster.ca for any questions.