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Investigator Initiated Projects

About the Program

A call for submissions will be made to the general CIRC membership annually. Members who wish to submit a proposal in-between those submission times (due to time-sensitive nature of the proposal) may do so through a request to the Director of Research, which will then be discussed amongst the Executive Board to deem whether it is appropriate for an Expedited Review.

Submissions & Review of Proposals

The first-round of call for proposals will request a 1-page (750 word limit) high-level summary of the study proposal, which will be reviewed by the Scientific Committee. Each proposal should outline study methods, include a sample size calculation, number of anticipated centres, duration of study and high level costings.

The Scientific Committee will be chaired by the Director of Research and will include the Vice-President, and at least three members at-large whose expertise will provide a balance of expertise in clinical trials, epidemiology, and health economics. Each member will review each of the summary proposals and rate on a scale of 1 to 5 for each of the following criteria: relevance/importance, quality of science, and feasibility. The proposals will be ranked based on total possible score of 15. The committee will review the scores and decided which proposals will be invited for full submission. The full submission will include a proposal up to 5 pages that will also include a budget. The research committee will review the full proposals and will decide which proposals should move forward to discussion with the Board of Directors. This will also be based on a score based on the rating scale used for the first round of reviews.

The Director of Research will present research proposals at a Board of Directors Meeting (President, Vice-President, Director of Research, Treasurer, Member-at-Large), which will make the decision whether to include the study on the agenda for discussion at the next General Assembly Meeting in early November. Based on discussion and input at the General Assembly Meeting, the Board of Directors will prioritize studies in queue based on feasibility, financial resources, type of studies, and other ongoing studies. The Board of Directors will work with the study PI to finalize the full study protocol, budget and develop strategies to secure funding.

Implementation

Once a study proposal in queue is ready for initiation, the PI will work with Research Director and the Vice-President to establish multicentre collaborations based on the existing CIRC network and an implementation plan.

Expedited Review

At the discretion of the Research Director, investigators may request that time-sensitive proposals be reviewed by the Scientific Committee outside the regular proposal submission cycle under an expedited review process. If the Research Director deems that expedited review is appropriate, he/she will ask the Scientific Committee to review it usually within 4 weeks. If the study is deemed to be scientifically meritorious and feasible, the Director of Research will present it at the next Executive Board meeting to determine whether a full protocol should be developed and approved. Studies that already have identified funding but would benefit from the CIRC network and infrastructure are examples of those appropriate for Expedited Review.

Update – CIRC’s 2021 Winter Call for Proposals is open!

Kindly note that all relevant information should be included in the body of the main proposal. Additional information (i.e. tables, figures, publications, etc.) may be included as appendices, but reviewers will not be obligated to read them. Also, please include up-to-date CVs of the study PI(s), highlighting current appointments and research accomplishments. CV’s are not required for co-investigators or collaborators. For more information, please read the Program Guidelines.

Submissions should be emailed to Dr. Sanjay Murthy (smurthy@toh.ca) as a single pdf file no later than 9 PM Pacific time (midnight EST) on February 28, 2022.